Some methodological difficulties in psychoneuroimmunological research
DOI:
https://doi.org/10.15291/radovifpsp.2574Abstract
The term psychoneuroimmunology refers to a relatively new multidisciplinary field of research which is aimed at the investigation of the dynamic interaction between the nervous, endocrine and the immunological system. The article gives a brief overview of existing investigations of the effect of stress on the immunological system and points to certain methodological difficulties of these investigations.References
ADER, R.( and COHEN, N. (1975): Behaviorally Conditioned Immunosuppression, Psychosomatic Medicine, 37, 4, 333-340. ADER, R., and COHEN, N. (1982): Behaviorally conditioned Immunosuppression and Murine Systemic Lupus Erythematosus, Science, 215, 1534-1536. ADER, R., and COHEN, N. (1991): The Influence of Conditioning on Immune Responses (private communication). ADER, R., COHEN, N. and FELTEN, D. (1995): Psychoneuroimmunology: Interactions Between the Nervous System and the Immune System, The Lancet, 345, 99-103. ALEGRETTI, N, ANDREIS, L, ČULO, F, MARUŠIĆ, M., TARADI, M. (1991): Imunologija, Zagreb, Školska knjiga. BASEDOVSKY, H.O., REY, A.E., and SORKIN, E. (1985): Immunoneuroendocrine Interactions, The Journal of Immunology, 135, 750-754. BENSCHOP, R. J., RODRIGUEZ-FEUERHAHN, M. and SCHEDLOWSKI, M. (1996): Catecholamine-Induced Leukocytosis: Early Observations, Current Research, and Future Directions, Brain, Behavior, and Immunity, 10, 77-91. BIONDI, M. and KOTZALIDIS, G. H. (1990): Human Psychoneuroimmunology Today, Journal of Clinical Laboratory Analysis, 4, 22-38. BLALOCK, J. E. (1989): A Molecular Basis for Bidirectional Communication between the Immune and Neuroendocrine Systems, Physiological Reviews, 69, 1-32. CANALS, J., COLOMINA, M. T., DOMINGO, J. L. and DOMENECK, E. (1997): Influence of Smoking and Drinking Habits on Salivary Cortisol Levels, Personality and Individual Differences, 23, 4, 593-599. CARROLL, D„ RING C„ SHRIMPTON, I, EVANS, P., WILLWMSEN, G. and HUCKLEBRIDGE, F. (1996): Secretory Immunoglobulin A and Cardiovascular Responses to Acute Psychological Challenge, International Journal of Behavior Medicine, 3, 3, 266-279. COHEN, S. and HERBERT, T. B., (1996): Health Psychology: Psychological Factors and Physical Disease from the Perspective of Human Psychoneuroimmunology, Annual Review of Psychology, 47, 113-142.DELAHANTY, D. L., DOUGLALL, A. L„ HAWKEN, L„ TRAKOWSKI, J. H„ SCHMITZ, J. B„ JENKINS, F. J. and BAUM, A. (1996): Time Course of Natural Killer Cell Activity and Lymphocyte Proliferation in Response to Two Acute Stressors in Healthy Men, Health Psychology, 15, 1,48-55. DUNN, A. J., (1989): Psychoneuroimmunology for the Psychoneuroendocrinologist: A Review of Animal Studies of Nervous System - Immune System Interactions, Psychoneuroendocrinology, 14, 4, 251-274. DUNN, A., J. (1995a): Interactions between the Nervous System and Immune System. Implications for Psychopharmacology, in: The Fourth Generation of Progress (Ed. Bloom, F.E., and Kupfer, D., J.), New York, Raven Press, Ltd. DUNN, A., J. (1995b): Psychoneuroimmunology: Introduction and General Perspectives, in Stress, the Immune System and Psychiatry (Ed. Leonard, B., Miller, K.), John Wiley and Sons Ltd. ESTERLING, B. A., KIECOLT-GLASER, J. K„ BODNAR, J. C. and GLASER, R. (1994): Chronic Stress, Social Support, and Persistent Alterations in the Natural Killer Cell Response to Cytokines in Older Adults, Health Psychology, 12, 291-298. EVANS, P., CLOW, A. and HUCKLEBRIDGE, F. (1997): Stress and the Immune System, The Psychologist, 7, 303-307. FLETCHER, M. A., IRONSON, G., GOODKIN, K„ ANTONI, M. H„ SCHNEIDERMAN, N. and KLIMAS, N. G. (1998): Stress and Immune Function in HIV-1 Disease, in: Handbook of Stress Medicine-. An Organ System Approach (Ed. J. R. Hubbard, J. R. and Workman, E.A.), New York, CRC Press. GLASER, R„ KIECOLT-GLASER, J. K„ SPEICHER, C. E. and HOLLIDAY, J. E. (1985a): Stress, Loneliness, and Changes in Herpesvirus Latency, Journal of Behavioral Medicine, 8, 3, 249-260. GLASER, R„ KIECOLT-GLASER, J. K„ STOUT, J. C„ KATHIEEN, L„ T„ SPEICHER, C. E. and HOLLIDAY, J. (1985b): Stress-Related Impairments in Cellular Immunity, Psychiatry Research, 16, 233-239. GLASER, R„ MEHL, V. S„ PENN, G., SPEICHER, C. E. and KIECOLT- GLASER, J. K. (1986): Stress-Associated Changes in Immunoglobulin Levels (private communication). GLASER, R„ RICE, J., SHERIDAN, J., FERTEL, R„ STOUT, J., SPEICHER, C„ PINSKY, D., KOTUR, M., POST, A., BECK, M. and KIECOLT
GLASER, J. K. (1987): Stress-Related Immune Suppression: Health Implication, Brain, Behavior, and Immunity, 1, 7-20. GLASER, R„ PEARL, D. K„ KIECOLT-GLASER, J. K. and MALARKEY, W. B. (1997): Plasma Cortisol Levels and Reactivation of Latent Epstein- Barr Virus in Response to Examination Stress (private communication). HERBERT, T. B. and COHEN, S. (1993): Stress and Immunity in Humans: A Meta-Analytic Review, Psychosomatic Medicine, 55, 364-379. IRWIN, M„ DANIELS, M., SMITH, T. L„ BLOOM, E. and WEINER, H. (1987a): Impaired Natural Killer Activity During Bereavement, Brain, Behavior, and Immunity, 1, 98-104. IRWIN, M., DANIELS, M., BLOOM, E. T„ SMITH, T. L. and WEINER, H. (1987b): Life Events, Depressive Symptoms, and Immune Function, American Journal of Psychiatry, 144, 437-441. IRWIN, M„ DANIELS, M„ RISCH, S. C., BLOOM, E. and HERBERT, W. (1988): Plasma Cortisol and Natural Killer Cell Activity during Bereavement, Biological Psychiatry, 24, 173-178. IRWIN, M„ CALDWELL, C., SMITH, T. L„ BROWN, S„ SCHUCKIT, M. A. and GILLIN, C. (1990a): Major Depressive Disorder, Alcoholism, and Reduced Natural Killer Cell Cytotoxicity. Role of Severity of Depressive Symptoms and Alcohol Consumption, The Archives of General Psychiatry, 47, 713-719. IRWIN, M„ PATTERSON, T., SMITH, T. L„ CALDWELL, C., BROWN, S. A., GILLIN, J. C. and GRANT, I. (1990b): Reduction of Immune Function in Life Stress and Depression, Biological Psychiatry, 27, 22-30. IRWIN, M„ BROWN, M„ PATTERSON, T„ HAUGER, R„ MASCOVICH, A. and GRANT, I., (1991): Neuropeptide Y and Natural Killer Activity: Findings in Depression and Alzheimer Caregiver Stress. Neural Modulation of Immunity, The FASEB Journal, 5, 3100-3107. IRWIN, M„ HAUGER, R., PATTERSON, T. L„ SEMPLE, S„ ZIEGLER, M. and GRANT, I. (1997): Alzeimer Caregiver Stress: Basal Natural Killer Cell Activity, Pituitary-Adrenal Cortical Function, and Sympathetic Tone, Ann. Behavioral Medicine, 19, 2, 83-90. JEMMOTT, J. B. and LOCKE, S. E. (1984): Psychosocial Factors, Immunologic Mediation, and Human Susceptibility to Infectious Diseases: How Much Do We Know? Psychological Bulletin, 95, 1, 78- 108.
KIECOLT-GLASER, J. K„ FISHER, L. D„ OGROCKI, P„ STOUT, J. C., SPEICHER, C. E. and GLASER, R. (1987): Marital Quality, Marital Disruption, and Immune Function, Psychosomatic Medicine, 49, 13-34. KIECOLT-GLASER, J. K. and GLASER, R. (1988): Commentary: Methodological Issues in Behavioral Immunology Research with Humans, Brain, Behavior, and Immunity, 2, 67-78. KIECOLT-GLASER J. K„ GLASER R„ GRAVENSTEIN S., MALARKEY W. B. and SHERIDAN J. (1996a): Cronic Stress Alter the Immune Response to Influenza Virus Vaccine in Older Adults, Medical Sciences, 93, 3043-3047. KIECOLT-GLASER, J. K„ NEWTON, T„ CACIOPPO, J. T„ Maccallum, R. C„ GLASER, R. and MALARKEY, W. B. (1996b): Marital Conflict and Endocrine Function: Are Men Really More Physiologically Affected Than Women? Journal of Consulting and Clinical Psychology, 64, 2, 324-332. KIRSCHBAUM, C. and HELLHAMMER, D. H. (1989): Salivary Cortisol in Psychobiological Research: An Overiew, Neuropsychobiology, 22, 150- 169. MALARKEY W. B„ WU H„ CACIOPPO J. T., MALARKEY K. L„ POEHLMANN M. and GLASER R., KIECOLT-GLASER J. K. (1996): Cronic Stress Down-Regulates Growth Hormone Gene Expression in Peripheral Blood Mononuclear Cells of Older Adults, Endocrine, 5, 1, 33-39. MANUCK, S. B., COHEN, S., RABIN, B. S„ MULDOON, M. F. and BACHEN, E. A. (1991): Individual Differences in Cellular Immune Response to Stress, Psychological Science, Research Report, 2, 2, 111- 115. MCCANN, B. S., BENJAMIN A. H„ WILKINSON C. W., CARTER J„ RETZLAFF B.M., RUSSO J., KNOPP R. H. (1996): Variations in Plasma Lipid Concentration During Examination Stress, International Journal of Behavioral Medicine, 3, 3, 251-265. NICOLSON, N. A. (1992): Stress, coping and cortisol dynamics in daily life, in: The Experience of Psychopathology: Investigating Mental Disorders in their Natural Settings (Ed. DeVries, M. W.), Cambridge, Cambridge University Press, 219-232. O’LEARY, A., (1990): Stress, Emotion, and Human Immune Function, Psychological Bulletin, 108, 3, 363-382.
SCHLEIFER, S. L, KELLER, S. E., MEYERSON, A. T„ RASKIN, M. L, DAVIS, K. L. and STEIN, M. (1984): Lymphocyte Function in Major Depressive Disorder, Archives of General Psychiatry, 41, 484-486. SCHLEIFER, S. J., and KELLER, S. E. (1992): Stressful Events, Depressive Disorders and Immunity, in: Psychoneuroimmunology. Interactions Between Brain, Nervous System, Behavior, Endocrine and Immune System (Ed. Schmoll, H.L. and Plotnikoff, N.P.), Lewiston, NY, Toronto, Bern, Göttinger, Hogrefe and Huber Publishers. SCHNEIDER, N„ JACOB, P„ NILSSON, F„ LEISCHOW, S. J., BENOWITZ, N. L. and OLMSTEAD, R. E. (1997): Saliva Cotinine Levels as a Function of Collection Method, Addiction, 92, 3, 347-351. SELYE, H. (1979): The Stress Concept and Some of its Implications, in Human Stress and Cognition. An Information Processing Approach (Ed. Hamilton, V., Warburton, M.), New York, John Wiley and sons. SELYE, H., (1982): History and Present Status of the Stress Concept, in Handbook of Stress (Ed. Goldberger, L. and Breznitz, S.), New York, Macmillan Publishing Co Inc. SGOUTAS-EMCH, S. A., CACIOPPO, J. T., UCHINO, B. N„ MALARKEY, W„ PEARL, D„ KIECOLT-GLASER, J. K. and GLASER, R. (1994): The Effects of an Acute Psychological Stressor on Cardiovascular, Endocrine, and Cellular Immune Response: A Prospective Study of Individuals High and Low in Hearth Rate Reactivity, Psychophysiology, 31,264-271. ŠIMIĆ, N. (1999): Efekti stresa na imunološki sustav, Magistarski rad, Filozofski fakultet, Zagreb. WEISSE, C. S., GALLIVEN, E. A., STERNBERG, W. F„ and SULLIVAN, E. R. (1998): Does Cortisol Mediate Stress-Induced Immune Changes in Humans? (private communication). WILLEMSEN, G. (1997): Secretory Immunoglobulin A and Cardiovascular Responses to Mental Arithmetic and Cold Pressor (private communication). ZEIER, H., BRAUCHLI, P. and JOLLER-JEMELKA, H.I. (1996): Effects of Work Demands on Immunoglobulin A and Cortisol in Air Traffic Controllers, Biological Psychology, 42, 413-423.
GLASER, J. K. (1987): Stress-Related Immune Suppression: Health Implication, Brain, Behavior, and Immunity, 1, 7-20. GLASER, R„ PEARL, D. K„ KIECOLT-GLASER, J. K. and MALARKEY, W. B. (1997): Plasma Cortisol Levels and Reactivation of Latent Epstein- Barr Virus in Response to Examination Stress (private communication). HERBERT, T. B. and COHEN, S. (1993): Stress and Immunity in Humans: A Meta-Analytic Review, Psychosomatic Medicine, 55, 364-379. IRWIN, M„ DANIELS, M., SMITH, T. L„ BLOOM, E. and WEINER, H. (1987a): Impaired Natural Killer Activity During Bereavement, Brain, Behavior, and Immunity, 1, 98-104. IRWIN, M., DANIELS, M., BLOOM, E. T„ SMITH, T. L. and WEINER, H. (1987b): Life Events, Depressive Symptoms, and Immune Function, American Journal of Psychiatry, 144, 437-441. IRWIN, M„ DANIELS, M„ RISCH, S. C., BLOOM, E. and HERBERT, W. (1988): Plasma Cortisol and Natural Killer Cell Activity during Bereavement, Biological Psychiatry, 24, 173-178. IRWIN, M„ CALDWELL, C., SMITH, T. L„ BROWN, S„ SCHUCKIT, M. A. and GILLIN, C. (1990a): Major Depressive Disorder, Alcoholism, and Reduced Natural Killer Cell Cytotoxicity. Role of Severity of Depressive Symptoms and Alcohol Consumption, The Archives of General Psychiatry, 47, 713-719. IRWIN, M„ PATTERSON, T., SMITH, T. L„ CALDWELL, C., BROWN, S. A., GILLIN, J. C. and GRANT, I. (1990b): Reduction of Immune Function in Life Stress and Depression, Biological Psychiatry, 27, 22-30. IRWIN, M„ BROWN, M„ PATTERSON, T„ HAUGER, R„ MASCOVICH, A. and GRANT, I., (1991): Neuropeptide Y and Natural Killer Activity: Findings in Depression and Alzheimer Caregiver Stress. Neural Modulation of Immunity, The FASEB Journal, 5, 3100-3107. IRWIN, M„ HAUGER, R., PATTERSON, T. L„ SEMPLE, S„ ZIEGLER, M. and GRANT, I. (1997): Alzeimer Caregiver Stress: Basal Natural Killer Cell Activity, Pituitary-Adrenal Cortical Function, and Sympathetic Tone, Ann. Behavioral Medicine, 19, 2, 83-90. JEMMOTT, J. B. and LOCKE, S. E. (1984): Psychosocial Factors, Immunologic Mediation, and Human Susceptibility to Infectious Diseases: How Much Do We Know? Psychological Bulletin, 95, 1, 78- 108.
KIECOLT-GLASER, J. K„ FISHER, L. D„ OGROCKI, P„ STOUT, J. C., SPEICHER, C. E. and GLASER, R. (1987): Marital Quality, Marital Disruption, and Immune Function, Psychosomatic Medicine, 49, 13-34. KIECOLT-GLASER, J. K. and GLASER, R. (1988): Commentary: Methodological Issues in Behavioral Immunology Research with Humans, Brain, Behavior, and Immunity, 2, 67-78. KIECOLT-GLASER J. K„ GLASER R„ GRAVENSTEIN S., MALARKEY W. B. and SHERIDAN J. (1996a): Cronic Stress Alter the Immune Response to Influenza Virus Vaccine in Older Adults, Medical Sciences, 93, 3043-3047. KIECOLT-GLASER, J. K„ NEWTON, T„ CACIOPPO, J. T„ Maccallum, R. C„ GLASER, R. and MALARKEY, W. B. (1996b): Marital Conflict and Endocrine Function: Are Men Really More Physiologically Affected Than Women? Journal of Consulting and Clinical Psychology, 64, 2, 324-332. KIRSCHBAUM, C. and HELLHAMMER, D. H. (1989): Salivary Cortisol in Psychobiological Research: An Overiew, Neuropsychobiology, 22, 150- 169. MALARKEY W. B„ WU H„ CACIOPPO J. T., MALARKEY K. L„ POEHLMANN M. and GLASER R., KIECOLT-GLASER J. K. (1996): Cronic Stress Down-Regulates Growth Hormone Gene Expression in Peripheral Blood Mononuclear Cells of Older Adults, Endocrine, 5, 1, 33-39. MANUCK, S. B., COHEN, S., RABIN, B. S„ MULDOON, M. F. and BACHEN, E. A. (1991): Individual Differences in Cellular Immune Response to Stress, Psychological Science, Research Report, 2, 2, 111- 115. MCCANN, B. S., BENJAMIN A. H„ WILKINSON C. W., CARTER J„ RETZLAFF B.M., RUSSO J., KNOPP R. H. (1996): Variations in Plasma Lipid Concentration During Examination Stress, International Journal of Behavioral Medicine, 3, 3, 251-265. NICOLSON, N. A. (1992): Stress, coping and cortisol dynamics in daily life, in: The Experience of Psychopathology: Investigating Mental Disorders in their Natural Settings (Ed. DeVries, M. W.), Cambridge, Cambridge University Press, 219-232. O’LEARY, A., (1990): Stress, Emotion, and Human Immune Function, Psychological Bulletin, 108, 3, 363-382.
SCHLEIFER, S. L, KELLER, S. E., MEYERSON, A. T„ RASKIN, M. L, DAVIS, K. L. and STEIN, M. (1984): Lymphocyte Function in Major Depressive Disorder, Archives of General Psychiatry, 41, 484-486. SCHLEIFER, S. J., and KELLER, S. E. (1992): Stressful Events, Depressive Disorders and Immunity, in: Psychoneuroimmunology. Interactions Between Brain, Nervous System, Behavior, Endocrine and Immune System (Ed. Schmoll, H.L. and Plotnikoff, N.P.), Lewiston, NY, Toronto, Bern, Göttinger, Hogrefe and Huber Publishers. SCHNEIDER, N„ JACOB, P„ NILSSON, F„ LEISCHOW, S. J., BENOWITZ, N. L. and OLMSTEAD, R. E. (1997): Saliva Cotinine Levels as a Function of Collection Method, Addiction, 92, 3, 347-351. SELYE, H. (1979): The Stress Concept and Some of its Implications, in Human Stress and Cognition. An Information Processing Approach (Ed. Hamilton, V., Warburton, M.), New York, John Wiley and sons. SELYE, H., (1982): History and Present Status of the Stress Concept, in Handbook of Stress (Ed. Goldberger, L. and Breznitz, S.), New York, Macmillan Publishing Co Inc. SGOUTAS-EMCH, S. A., CACIOPPO, J. T., UCHINO, B. N„ MALARKEY, W„ PEARL, D„ KIECOLT-GLASER, J. K. and GLASER, R. (1994): The Effects of an Acute Psychological Stressor on Cardiovascular, Endocrine, and Cellular Immune Response: A Prospective Study of Individuals High and Low in Hearth Rate Reactivity, Psychophysiology, 31,264-271. ŠIMIĆ, N. (1999): Efekti stresa na imunološki sustav, Magistarski rad, Filozofski fakultet, Zagreb. WEISSE, C. S., GALLIVEN, E. A., STERNBERG, W. F„ and SULLIVAN, E. R. (1998): Does Cortisol Mediate Stress-Induced Immune Changes in Humans? (private communication). WILLEMSEN, G. (1997): Secretory Immunoglobulin A and Cardiovascular Responses to Mental Arithmetic and Cold Pressor (private communication). ZEIER, H., BRAUCHLI, P. and JOLLER-JEMELKA, H.I. (1996): Effects of Work Demands on Immunoglobulin A and Cortisol in Air Traffic Controllers, Biological Psychology, 42, 413-423.
